4/5/2023 0 Comments Ohapi sickle cellSuch people are also referred to as carriers. A person with a single abnormal copy does not usually have symptoms and is said to have sickle cell trait. An attack can be set off by temperature changes, stress, dehydration, and high altitude. Several subtypes exist, depending on the exact mutation in each haemoglobin gene. Sickle cell disease occurs when a person inherits two abnormal copies of the β-globin gene ( HBB) that makes haemoglobin, one from each parent. The average life expectancy in the developed world is 40 to 60 years. Long-term pain may develop as people get older. A number of health problems may develop, such as attacks of pain (known as a sickle cell crisis), anemia, swelling in the hands and feet, bacterial infections and stroke. Problems in sickle cell disease typically begin around 5 to 6 months of age. This leads to a rigid, sickle-like shape under certain circumstances. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. The most common type is known as sickle cell anaemia. Sickle cell disease ( SCD) is a group of blood disorders typically inherited from a person's parents. Life expectancy 40–60 years (developed world) Vaccination, antibiotics, high fluid intake, folic acid supplementation, pain medication, blood transfusions The inset image shows a cross-section of a sickle cell with long polymerized sickle haemoglobin (HbS) strands stretching and distorting the cell shape to look like a crescent moon.Īttacks of pain, anemia, swelling in the hands and feet, bacterial infections, stroke Ĭhronic pain, stroke, aseptic bone necrosis, gallstones, leg ulcers, priapism, pulmonary hypertension, vision problems, kidney problems Figure (B) shows abnormal, sickled red blood cells sticking at the branching point in a blood vessel. The inset shows a cross-section of a normal red blood cell with normal haemoglobin. Figure (A) shows normal red blood cells flowing freely through a blood vessel.
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